CloneCD is my first choice when I can use it. I still love the interface the best. Then Blindwrite with the tweaker if I have to backup Securom 4.7+ games, since I have a Plextor Premium. I refuse to emulate, so if I can't copy a title, I just use Daemon tools.
All of them get blacklisted every so often, so you have to play around with them all from time to time.