I am not entirely sure what you are asking but I will try.
If you are running a SafeDisc 3.15 backup from a read only drive only (CD ROM/DVD ROM), you will not need an ATIP hider, therefore you should not have to activate any of CloneCD's features. But some reports suggest that no matter what you try to do, the best thing would be to uninstall CloneCD all together.
The drives that may have some trouble are the burners. They need an ATIP hider (CloneCD's Hide CDR) if running a newer copy protection scheme. This means enabling some of CloneCD's features, which means that CloneCD is probably gonna be detected while the guard module in the program's exe runs.
BUT CloneCD can overcome blacklisting by updating their program.