People on the site have had some issues with the 5280 and high-speed CD writing. The quality is not consistent across all drives; for the affected drives, you could expect high jitter & a few C2 errors at speeds higher than 32x. 24x and 32x were okay. 16x and lower were fine. And there really was never an explanation as to why things varied from drive to drive. Most people kept their 5280S anyway OR they managed to exchange for a better unit, so the issue wasn't too bad.
DVD writing was said to be OK (not amazing, but good enough). I don't think anyone ever said how well the drive was able to read, but my guess is that it's probably average or OK. The drive seems all-around average, and none of the drives these days are amazingly fast at reading. ]
At the very least, though, Optiarc drives report more information when doing CD scans and are probably better at telling you when discs are good. That way, if you got the 5280S, it could be a primary CD scanner (the LiteOn only indicates the worst types of C1 and C2 errors, while the 5280S reports those and minor C1 and C2 errors), and it can be a secondary DVD scanner (the LiteOn reports jitter on DVDs, which the Optiarc does not). That might work better when it comes to ripping audio discs.
...Which Pioneer drives do you have now?