There are PKZIP-style programs that will break up files into X-size chunks. And I've done Data Backups to CD and DVD that the burning program understood was "too large to fit on one disk - span disks for a backup set?" mentality. (Roxio, Nero, etc.)
I learned to avoid those because, should one disk or file-set be corrupt, then none of the files can be restored easily, if at all.
So now I use the manual "fill it up, back it off" approach and I know I've got a 'full enough' disk that can serve as both a backup 'set' by my own labeling, and a standalone disk. Time-consuming, yes, but Restoring Files is the name of the game. Making that more certain, and easier, is more important to me than "easy backups" - if I can't restore them, then why pretend to back them up?