I wonder if someone knows the best settings in CloneCD for this hardware:
Toshiba sd-m 1502 for reading
Plextor 24x10x40x for writing

It totally depends on which protection you’re trying to copy… The hardware you mention is very good so it can almost handle all known copy protections but like I said different protections need different settings. To know which protection you game has (and thus which settings you should use) try a copy-protection scanner like ClonyXL