My setup is pretty near to what Sean does.
All the drives inside the PC (9 of them) are SSD’s.
The NVme drive is the system drive. Half of it is used as a scratch disk for audio and video editing, and the completed files are then stored on one of 3 SSD’s specifically used for audio and video editing.
Another one of the SSD’s (528GB) is used only for Macrium Reflect system backups. It’s great to be able to restore the system drive quickly.
All data files are then backed up to an external 8TB USB3 HDD which is encrypted using BitLocker.
Most of the SSD’s require specific software for maintaining them, such as secure erase. That required 4 or 5 USB flash drives to boot from, because in most cases you cant SE an SSD that is a system drive. Plus another USB flash drive for Macrium Reflect restores.
I got fed up with that, and made a USB3 (live) full Windows 10, booting and running from USB3. Now I have all my tools usable from one session.