One thing that you said concerns me the most "the same now happens to my original disc"
Once an original can't be played, aside the factor of blacklisiting, such as Virtual Drives, which you say youhave none installed, it becomes a software issue. Your backups may all be good, until you get the original to work, don't jump the gun to say the backups are all no good.
You must investigate this matter by troubleshooting the game from the original discs until it works. Check drivers, windows updates, possible conflicts, nforce drivers?, DMA?, update Video Card Drivers?, SIS chipset?, motherbaord drivers, Directx, etc... all the usual steps.