Yes, you can. However, the question is how you are getting the files to the PS3. If you are steaming them to the PS3 via a Tversity, WMP11, or something similar then you should instead use the VOB device which will keep large movies all in one file. There is only one profile under the VOB device so no default is required.
If you are transferring to a portable hard drive (FAT32) and need the 4GB file splitting feature of the PS3 Vob Passthrough then you will need to copy and set the profile as default manually since DVDFab disables the “Set as Default” button on VOB profiles (for some unknown reason).
[li]The file you are looking for is called “ps3.vob.passthrough.xml” and can usually be found in C:\Program Files\DVDFab 5\Profiles.[/li][li]Right click on the file an select copy then navigate to C:\Documents and Settings<Your User Name>\Application Data\DVDFab\profiles and paste the file.[/li][li]Rename the new file to “ps3.default.xml”.[/li][li]Edit the file with notepad and change the value on the first line from tag=“dvdfab” to tag=“dvdfab,default”.[/li][li]Restart DVDFab[/li][/ul]