If you get a message coming up when you reach the splash screen of the game, then your copy needs emulation. You should go into the Alcohol 120% main screen, Then go to 'Emulation' in the left menus. Ensure 'Ignore Media Type' is enabled, and then go to 'Extra Emulation' then check 'BAD Sectors Emulation'. Then try running your game.
If that doesnt work, you're going to have to use CloneCD, which is best for SafeDisc v2.9 I think.