My NForce 2 board (MSI K7N2G-ILSR) isn't giving me any problems with the latest version of Plextools and my Plextor 40x CDROM and 12x Writer, but they both are SCSI.
I guess the problems are with the IDE driver. There are some older programs that are giving problems on NF2 boards, especially when making use of the NVidia drivers with Windows XP.
I don't know what OS you are using, but try to revert back to the original MS IDE drivers if you are in XP (other OS' don't use the NVidia drivers) and try again.
Nero CD Speed had a similar issue, that was solved with an update of CD Speed.