Optorite and nForce issues

Anyone know of any issues with using a Optorite DDO203 (2.50firmware) with an nForce motherboard? I have a Epox 8RDA6+pro that I just put togather, as soon as I install nForce drivers it will not boot to windows, I have to use last known good to get in. As soon as I disconnect the drive it all runs great. The drives are set up correctly and I had the same setup on a Via board working fine. Any info welcome. :confused: