I could not get Nero 188.8.131.52 to install in Vista, it would just hang. So I deleted the registry entries, the temp files, etc, several times. Finally out of frustration, I decided to empty the Recycle bin, and give up - well Windows Explorer hung.. after restarting it still hung.
I tried to explore a drive - the drive I picked was a FireWire drive, that I just attached (that morning) to the Vista PC, explorer hung on that also. I rebooted, and found that I could explore C: and D: I turned off the the Firewire drive - and presto - Nero installed!