I did uninstall CloneCD and CloneDVD. No joy. I didn't think that would make a difference since I have CloneCD, AnyDVD and CloneDVD on my laptop and the back up works fine on it.
My best guess is it's either the OS (XP Pro), the trial version of Alcohol, or the DVD player (not a burner). I could also have some residual registry entries from some piece of software I installed long ago and forgot about. That's happened before.
It's not a big deal. I didn't want to purchase another copy of Alcohol anyway (When the trial version of Alcohol expires on my desktop). I'll just use the backup on my laptop and keep the original tucked safely away. (Kicking myself for registering Alcohol on my laptop though)