Well that depends on what you mean by "have it work ok", if you burn the ISOs (as data) directly to DVD, and use a tool like Daemon to 'mount' the images, then yes, it will work. When installing the game you will then need to unmount disk 1 and mount disk 2 (etc.) when prompted during the install process. If you mean to create a single, seemless install process that does not require switching disks, it is possible but may require some tweaking. What kind of tweaking exactly depends on the specific game.