I've been using Malwarebytes, both the unpaid and PRO versions now for a couple of years and this is the first time I can every remember them having a major problem with an update. Thankfully I haven't had a problem on my Windows machines.
In contrast Windows updates/patches have caused numerous problems over the years. However, my favorite offender was Zone Alarm. About every 2-3 months one of their updates would knock me off the internet with no warning. The first two times it freaked me out and I did antivirus and malware/adware scans and then checked to see if an update was the problem. After that I just hit system restore and then I'd find out later that yet again one of their updates had screwed up. Eventually I grew tired of this and switched to Comodo. Poof, no more update problems with the firewall.