ISO backup won't run on virtual drive may be protected and wants to load from the original CD Rom Drive

Hi Newbie here needs help
Is this the correct forum.
sorry really old pc guy here trying to catch up
I have done a lot of research but need help
I have a programme I want to run from a virtual CDRom drive
So i made an iso using Magic Iso and then with protection ID V6. I mounted the iso files in virtual drive but they won’t play. I know one must be protected and the other is programmed to run from the CD Rom drive when it is the D Drive. How can I make it work?