If you're trying it with CloneCD, ensure the CloneCD tray is running, and the option 'Hide CD-R Media' is checked. Ensure you have the latest version, which is CloneCD 5.1 at the time of writing, and then try.
In Alcohol 120%, In the Emulation options enable 'Ignore Media Type' and then go to 'Extra emulation', then check 'BAD Sectors Emulation'. Ensure you have the latest version which is 1.9.5 at the time of writing.
Try burning it to a media and use your Plextor Premium for both reading, writing and playing the game, and ensure you read and write at 4x. The Premium skips SD errors quite fast.