I have made backups of almost every game I have and have never had a problem.
I always use my Toshiba DVD drive as the reader and my LiteOn to write. When reading SafeDisk 2 and especially SD 2.51 it takes an amazingly long time to read the disk. But my DVD drive usually finishes in around 12 min. Not bad. But, for the first time, I used my LiteOn drive yesterday and low and behold, it only took 7:43 to read it! For me, that was an amazing speed increase. So, now I use my LiteOn as the reader.