Only difference seems to be the selectable background lighting.
For LoL, a “MMO Mouse” might be better, though the extra buttons may be a bit small and fiddly.
Another MMO, larger buttons
The key point of the MMO mouse, is that it has a lot of extra buttons for what would otherwise be keyboard functions, though getting used to extra buttons (even going from 3 to a 5 with sideswipes) takes some time - I still accidentally hit the sideswipes!