Every few revisions, SafeDisc introduces new weak sector patterns that the Litey can't handle. alexnoe updated his batch program to reflect these patterns. While the ASUS is not a three-sheep burner it didn't have the problems of some LITEONs.
You have to be lucky to buy a LITEON that can defeat SafeDisc as easy as any ASUS except the 32x. The context to this is using any program to backup. The true tests are a CloneCD read/write or a DiscJuggler read/write. We know of no 24102B that can write SD2.9x
The ASUS also doesn't have the unreliability of a LITEON, generally speaking because some just can't do it, for a SecuROM read.
If anyone is about to flame me: if your LITEON works for you then w00t! If yours doesn't then you can still backup with autoplay or some other form of emu. CloneCD's VCD has been blacklisted by SecuROM and SD2.9x Blacklisting proves the importance of hardware/software combinations that you are happy with.