I think that you and I are having a similar problem.
Had this problem with the ND-1300a, no such issue with my Plextor 708A, but it's back with a newly acquired ND-2500a.
If I burn .iso images, it reports:
You are about to create a multi-session write once DVD disc. Session no. 2 and above will not be readable with some DVD-ROM drives and operating systems prior to Windows XP.
How do you want to continue?
Burn multisession anyway
Burn without multisession
Clicking on Burn multisession anyway results in a perfectly usable disc, but if I create a DVD-Video using the Nero template, drag the VOB files I want to burn into the template's VIDEO_TS and attempt a burn, the thing starts to write the lead-in before becoming completely unresponsive. The only option I have at that point is to reboot the system.
At first I thought it was due to the cheap DVD-Rs I was throwing at it, but it happens even with expensive / retail / name brand media. Application used to burn and/or version of the application doesn't seem to affect the results.