That sounds like a graphics (or graphics driver, since you tried it in Safe Mode, where certain drivers aren’t loaded) problem.
Probably happened simply because those drivers weren’t loaded is all.
I have an E520 myself (which came with an ATi Radeon X1300PRO video card. The PC also has onboard graphics, but mine is disabled).
Can you have a look in Device Manager, and tell us what video card you have (listed under “Display Adapters”).
Also, the name of the game you’re trying to run would be useful, just to make sure your video card is up to snuff