Like theEye mentioned, from my experience, the transfer rate between UDMA Mode 5 & 6 is not noticeable. The only time it would likely make a difference is if you’re using two UDMA 6 HDD’s on the same channel either as raid or when transferring data from one HDD directly on to the other on the same channel, but even still, the difference would be very small.
In fact, switching off your virus checker temporarily for the duration of a massive data transfer between two HDDs would have a far more significant effect on transfer rate.