First suggestion is to use one of your other computers to make a new copy of the disk.
Use good media, like AZO Verbatim and burn at a reasonable speed. If using a laptop to make the new disk, use ImgBurn (free burning program) and burn the Verbatim disk at 6x.
It sounds like the drive in your computer isn't a particularly good reader, or this one disk isn't burned well. You can try cleaning the lens of the drive also, to see if this helps.