I've gotten the free version to work under Wine but only using full DVD. Anything with a popup frame will crash it so customize doesn't work. If you want to change a customizable feature then you need to edit the Wine registry by hand. DVDFab is unable to find it's key in Wine so the paid version has not worked for about a year (see other thread on this).
DVDFab 5 under VirtualBox works pretty well but you do have to configure direct passthrough of the dvd-rom drive. The only thing that is broken is when you change the DVD you have to restart DVDFab for it to see it.