DVD Drivers disappear

I have a weird issue with CD ROM/DVD that is periodically disappear during the session (that happens after running Outlook, Skype or some other applications). After I’m uninstalling the drivers in the device mgr and rebooting, the Windows sees it again (but till the some moment - see above).

I’m using Windows 7 64 bit.

Thanks in advance for your help.

What kind of computer are you using? Is it a homebuilt PC? If so, what Motherboard is in the system?