Hey Jason. Yes it can mess things up. But that doesn't necessarily mean that you did mess anything up. You didn't say if this was a hard drive or an optical drive. If it's a hard drive, just run scandisk to check for errors or problems. If it passes that, it should be fine. If optical, should be no harm, no foul. You should always use ctl/alt/delete, and stop the process, then on task bar, click on the usb device and remove it, before unplugging the device. That is the safe way to do things.