I've never tried it with Home Premium so I would just be guessing. All I know for sure is that it won't work on my Intel Pentium D 950 (3.4Ghz) which is in a Dell XPS-400 running Vista 64 Ultimate Edition. I have the same problem that you can find in several places on this board where DVDFab Platinum will ask for the key then crash. Any attempt to run it after that will result in an immediate crash. If I remove the key from the registry, it will run again and ask for the key (with the same results).
The Patin-Couffin drivers run fine on the system and will respond correctly to all commands. Also, DVDFab Decrypter runs perfectly on the system.
Besides the Dell XPS, I've tried this on a Dell Latitude D-620 Laptop with an Intel Core 2 processor and Vista 64 Ultimate Edition with the same results.
By the way, I've found something very peculiar about this problem: if I just enter the last 2 characters of my key, DVDFab Platinum will crash just as with the entire key. If I enter any other key sequence besides the entire key or the last 2 characters of the key, it will simply ask for the correct key. Weird.