Hi Mick and welcome to the show.
The main reason to disable Autorun is that some common malware depends on being allowed to run on your system thereby infecting it before your defending software is able to scan it. That goes for CDs, DVDs, HDDs and USB sticks and storage cards.
The best policy therefore is to connect the device, then right click it and run a scan with your up-to-date antivirus program or something like Malwarebytes. If that is all clear, then go ahead and run whatever it is on the device that you are interested in.
It only takes a few seconds and is MUCH safer!
PS. Why is this question being asked in the DVD Fab forum? Perhaps a mod would like to move it to somewhere more appropriate...?