Use good quality media (Memorex, Sony, Ritek, Princo, Fuji, TDK from Costco, and Maxell that are not made in Japan are not good quality media). Are you using inferior blank media? If you're not using Taiyo Yuden (not valueline), Verbatim, Verbatim Datalife Plus, or Maxell Broadcast Quality, then chances are the answer is yes.
If you use poor quality blank media, then you should expect problems.
For +R DL blank media, use Verbatim made in Singapore only.
Try lowering your burn speed (not below 4x; if you have a 16x burner and 16x rated media try writing to it at 12x instead of 16x; an 8x burn speed on 16x rated media wouldn't be a bad idea either)
Bad quality blank media can vary in results from disc to disc, even within the same spindle. With good blank media you can play "find the bad blank" game. With inferior quality blank media you get to play "find the blank that works" game. And even when inferior blank media does work, you can play the "will my backups still play after 6 months (or even after two years)" game.
Use good quality blank media (Taiyo Yuden Premium, Verbatim Datalife Plus, Maxell Plus, Maxell Broadcast Quality). Avoid Ritek, Memorex, Regular Maxell blank media that you can find in most stores that are not made in Japan, Fuji, TDK from Costco, and Princo. Also, on average, it's wise to avoid blank media that's made in China or Hong Kong.