The only part I can help with is AnyDVD. If you intend to do full rips, with no compression or removing extras, then the built-in ripper within AnyDVD will work just fine for this process.
There will be no loss of quality doing straight 1:1 rips with AnyDVD. The only thing you lose will be the copy protection/encryption put on the dvds to "prevent" copying.
If the size of the files was a problem, I'd suggest using DVDShrink in combination with AnyDVD to remove extra sound tracks, commentary, etc. You can set it to No Compression when doing this, but if you use ReAuthor mode in DVDShrink, you lose the menus. With 4.5tb of space this may not even be a consideration for you.