Do you have AnyDVD running? What version? Is your CloneDVD also 100% current?
What is the text of the error message you receive?
Depending on your error message, maybe we should have you try to rip the original with "AnyDVD Ripper" and then process the movie, with CloneDVD, from you HDD rather than direct off the DVD drive.
The studio that produced this dvd has obviously got new technology in place that causes CloneDVD2 to fail when it tried to copy the DVD
More likely that your AnyDVD is not the latest or if it is you have discovered a new variation on a protection used in R4. If so we'll have you send the disk info to Slysoft.
All depends on your response...