Fireburner doesn't have many settings as such. The most important thing to do is to remember to select the create a cue sheet option when making the CloneCD image.
Then start FireBurner and check that the burner you want to use is selected [if you have more than 1] and then select 'Load Cue sheet' from the file menu. FireBurner will load the cue sheet and then you're pretty much set to burn.
Burning speeds will be dependant on whether your drive is fully supported by FireBurner or not. My Asus CRw 5232AS isn't so I get the choice of 1x or Max for burning. If you're burning game images then I would suggest 1x which although slower will give you a better burn in that it is more likely to authenticate the game you are trying to backup.
I've not had the need to back-up a PC game for some time now, in fact the last version of SafeDisk I remember sucessfully duplicating this way was 3.20.