You patched Vampire: The Masquerade - Bloodlines to higher version as this normally upgrades the used protection (in this case SafeDisc 3.20 game version 1.0) to a higher version and SafeDisc doesn't like CloneCD beeing on your System. Although these blacklisting get fixed from Slysoft from time to time I would upgrade the the newest version if you haven't already done this?
Beside the above mentioned problem the settings for your backup would be using Protected PC Game profile for reading and writing and enable Hide CDR Media in CloneCD System tray.
p.s. Use aray scanner www.aray-software.com for checking the used protection.