I ran into this problem, and in my research, I've found a few things. Here is the one I'd suggest to try:
There are known problems causing this message, both resulting from third-party software using debugger-like approaches.
Nero 6 ultra edition - specifically Image Drive can cause this issue
Use the Nero â€œgeneral clean utilityâ€ - available from the Nero website to remove the offending program and then the game works.