i dont think it matters for the installation ive installed nero with antivirus resident protection on many times and it worked fine but i guess you got nothing to lose by tryin , anyway regardless to the question disabling the antivirus resident protection while burning is always a good thing as it can make the burn fail cuz the resident scanner will check every file while the burning software will try to burn it
install forceaspi http://radified.com/ASPI/forceaspi.htm,
disable the imapi service goto start>>run type cmd and press enter put this and press enter
sc config imapiservice start= disabled
if these wont do the trick then remove the upper/lower filters as desribed in this article http://support.microsoft.com/default.aspx?scid=kb;[LN];314060
edit what nero version is it?