I assume this will be Win7 64?
This could be the motherboard, and it's got 4 SATA3 ports and 4 SATA2's.
If you wanted to go save some dollars, you could find a SATA2 boot-drive or SSD (90-128Gb - something in the sub-$100 range) and then have a much larger SATA3 hard drive for D: and your data and games. Seagate 3Tb 7200s are $149, and $180 gets you into WD "Black Series".
I use either 2 sticks of memory or 4 (not 'just 3'), although I think that ASUS board offers a RAMDisk utility if you'd want to experiment with it. Say, setting up a RAM disk from the RAM 9Gbâ†’12Gb, and tinkering with it. RAMDisk utilities can be fairly fun like that - and relatively safe for experimentation. Most of those are 'checkbox' utilities where a few standard recommendations are offered, you can "Check" them, reboot and see how you and the computer work together. No likee? Uncheck, and reboot. The RAMDisk utilities are also a "Load at Startup? YES NO" function so you can 'turn it off', too.
But I'd try to find a matching 4th stick.
ASUS has a nice overclocking utility, as well. This usually scores 'best' among the auto-overclocking utilities, although manual tweaks usually can get it somewhat higher. A better CPU cooler is recommended for any overclocking.
The industry is in a 'shift phase' for optical drives at this point. DVD-Burners ($15-25) are being phased out of production and BluRay burners ($60-100) are now the only offerings for some brands. There are a lot of discussions about "best drives", but inside all of those is the equally raging debate of "what brand of blanks works best with Drive XYZ?" too. It's a tad complicated, let's say.