In Theory nothing can happen because all drives of the last 15 years should have a buffer underrun prevention. But some drives mess up if it stop burning x-times because the buffer always gets empty.
U can make a burn and start gaming, after that you can take a look how long it takes. If it is a similar time like a burn without gaming it should be no problem.
Without a drive which can scan it is hard to see how good the burn really is. All drives should be able to make a transfer test with CDSpeed, if the speed never drops and no read error it´s a sign that the burn is at least not that bad. You can also use the scan-function in CDSpeed to see whether it´s all green.
But a drive for quality scan like a Liteon ihbs x12 or a specila LG-drive (or crossflashed BH16NS55 to WH16NS58) is still the best way to test burn quality.
My experience is 4x-burns with BD-R is mostly better than 6x, but with good media the difference is not that big
Which drives and which media u use?