Peris77...this guide is showing a bit of age, simply because jdobbs keeps adding new bits into the program. But for the basic setup it should still be a good introduction.
In the Mode selection, you should pick Movie-Only Backup, unless you want a menu as well. Most people don't want or need the menu when making a movie without extras, but jdobbs has added the Movie and Menus for those who do.
The Quick Play option is something in between. It keeps all significant playlists (above a certain size) but has no menu. This allows you to select extras by using your remote control on your player, but not through a menu within the encoded movie. You simply hit menu on your controller and cycle through the main movie and extras in that manner. I have never used this option.
In Setup you should select Italian as the main language and subtitle language.
To get the best quality encode, you should use a two pass encode. If you have a lot of time, use the encoder setting Highest (very slow). I personally use the High setting quite often instead and have been very pleased with the results. A one pass CRF encode should also be quite good. I use the CRF setting sometimes when I don't need much compression to fit onto a single layer blu ray.