Which drive letter is assigned to your blu ray drive, and does a tab with that letter show up in the main screen of AnyDVD HD? Do you have Enable Blu Ray support checked under the Video Blu Ray settings? Obvious questions, but need to be confirmed.
Which make and model drive do you have?
Edit: More questions. Does the drive play blu ray disks properly? Have you looked in Device Manager to see if there are any problems indicated with the drive? Does your burning program recognize the drive?