Safe mode won't have any effect on those two products at all. The reason safe mode was enabled by default was because of issues people were having with certain RAID configurations. In that case, enabling safe mode is necessary and will affect the proper operation of CloneDVD and CloneCD with regard to AnyDVD. James will probably chime in on this one, but, I just wanted to give you the answer he's likely to give. If you don't have RAID and are only using Slysoft products, then it's not going to affect you either way.