The change which seems to cause this problem is, that AnyDVD locks the filesystem for exclusive use, makes its changes, and releases the filesystem again. This was done, so software accessing the drive is notified of content change (if you altered settings, or disabled/enabled AnyDVD).
The problem with early 4.x versions was, that a devicechange could be broadcasted while AnyDVD has locked the filesystem. Such a broadcast would be unnoticed by explorer as AnyDVD has still locked the media for exclusive use, so autoplay would not work. Depending on the system configuration this race condition could cause AutopPlay to malfunction.
220.127.116.11 should not have this problem anymore, because it always unlocks the filesystem before the devicechange event occurs.
I don't know, why you still have problems. But I have prepared a beta version with a different locking, which hopefully solves your problem. I have sent you the link via PM.
Please let me know, if autoplay now works as expected.