Able to read Some DVD Disk

I am not sure if this is Hardwarde or Software Related, and if so thanks for your help.

I recently got a new system, Asus P5W DH, Nvida 7950 With a Pioneer 112 and an LG Sytem drive, It will Read DVD Like Vista OS and Office 2007, but DVD like BF 2142, and Supreme Commander are installed the AutoRun will work But Vista Explorer does show any files, If I open a Command prompt I can view the directory.

If I Run the setup.exe From the Cmd promt Vista give me a BSOD. This happens from either of the Drives in the system, and Another drive I Tried in the system.

I’ve Flashed the MB Bios, and upated the firmware, IS this a OS isue or something else?