Yeah, use an MD5 generator and verifier.
I use MD5 summer. It's freeware.
This link will explain what md5s are:
It's basically a hash-checker to verify that the files on your dvd/cd match the ones burned to your hard drive.
I do it all the time... takes awhile to generate and check md5s, but it's worth it for my peace of mind.
I set up a folder before burning, and put the md5 in that directory, along with all the data I want to burn (including sub-folders of files); let's call this folder "To Burn". I then burn the dvd from the "To Burn" folder, and then open the md5 file (freshly burned) from the dvd copy and have MD5 Summer check the data on the dvd.
You may have to mess around with it awhile to see how it works.