Same here Alan.
R1, WS, Platinum 220.127.116.11 Beta, PP enabled, did main title, English audio and English subtitles in Customize mode. No problems at all.
I'd definitely try Alan's suggestion about cleaning the disc, even if it looks pristine.
If no go, try changing the PathPlayer settings...
ie., PathPlayer enabled or completely disabled and not enable if necessary.
You can also try reading this disc in another ODD...if you have one available.
Is this the only disc giving you problems?